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Christina Applegate’s Candid MS Battle: Pain, Depression and Resilience

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Christina Applegate, the 52-year-old actress, recently shared her personal struggles with multiple sclerosis (MS) on her “MeSsy” podcast. She revealed that her battle with the chronic disease, which affects the brain and central nervous system, has been particularly challenging recently due to a “pretty bad” relapse.

Applegate confessed to her co-host Jamie Lynn-Sigler, who also has MS, “I’m gonna be honest with you, I need to buy stock in Cottonelle because I haven’t taken a shower in three weeks.” The reason, she explained, is that she can’t stand in her shower due to the severity of her symptoms.

She further explained, “I have such a small bench and my a– is so huge these days that I can’t sit on it, it’s like I slip right off of it.” As a result, she’s been using Cottonelle wipes to clean herself, though she expressed doubt about their effectiveness, saying, “I smell so bad. And it’s, like, awful. Thank God I’m always alone so that no one smells me except for Sades,” referring to her daughter Sadie.

At the start of the episode, the “Married…With Children” alum detailed the severity of her symptoms and how they were affecting different parts of her body. She shared that she was experiencing “intense pain” in her legs that made her unable to walk to the bathroom due to her fear of falling.

Applegate also described suffering from “insane tingling” that radiated from her backside down her body. She revealed that she was unable to sleep due to movement problems in one of her eyes. “I haven’t slept for 24 hours because my eye is doing something weird, where every time I close my eye to go to sleep, my right eye starts to shift like this,” she said.

After doing some online research, Applegate discovered that her eye problems could be a symptom of MS resulting from possible damage to the optic nerve in her right eye. “I couldn’t sleep because every time I would close my eyes, my eye would start doing, like, crazy s—,” she explained. “So I have been up for over 24 hours.”

When asked if she had contacted her doctors about her relapse, Applegate admitted that she had not yet been able to reach them. “I’m going to have to go in and see someone because it’s a little scary and it’s freaking me out that, like, my eye is, like gonna burst out of my face or something,” she said. “So I’m a little concerned about that. My legs have never been this bad, so I don’t know what’s going on. Like no energy. Legs are just — just done.”

Applegate also shared that she’s been struggling with depression since returning from a vacation. “You just lay in a dark room watching TV and wanting it all to just go away. And that’s kind of where I’m at,” she admitted.

Applegate publicly announced her MS diagnosis in August 2021, which she received a few months prior. The diagnosis led to a five-month halt in production on the last season of her hit Netflix show “Dead to Me” as she began treatment.

“I got diagnosed while we were working, and I had to call everybody and be like, “I have multiple sclerosis, guys. Like, what the f—!”, she told Variety in November 2022. She also shared that filming the third and final season of “Dead to Me” was the “hardest thing I’ve ever done in my life.”

Applegate also revealed that she had noticed warning signs of MS for years before her diagnosis. “I started thinking about the last four years, and I had very small symptoms,” she said. “So it presented itself like a few years ago until it just got as bad as it did.”

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  1. Ann

    April 8, 2024 at 5:44 pm

    So sorry to hear you are suffering so much my sister had it and her legs were a problem, I hope that some of the medications will help you. Saying lots of prayers for you to improve 🙏🏻🙏🏻🙏🏻

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The Surprising Link Between Bathroom Habits and Organ Health: What Experts Want You to Know

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The health of your kidneys and liver, indispensable organs in your body, play a pivotal role in maintaining your overall wellness. They take on multiple indispensable tasks, predominantly executing the crucial function of waste filtration. Maintaining these organs in a healthy condition often involves a multifaceted approach, encompassing a nutritious diet, consistent physical activity, and moderated alcohol consumption. However, recent studies bring our attention to a surprising aspect that may potentially impact your kidneys and liver adversely: the frequency of your bowel movements.

In an intriguing research endeavor, analysts from the Institute for Systems Biology (ISB) took on the mission to comprehend what the regularity of an individual’s bowel movements might indicate about their long-term health. The results, published recently in Cell Reports Medicine, are based on the detailed analysis of medical, lifestyle, and multi-omic data obtained from over 1,400 healthy adults.

Through a careful examination of this data, the researchers have identified four distinct categories of self-reported bowel movement frequencies: constipation (one to two bowel movements per week), low-normal (three to six bowel movements per week), high-normal (one to three bowel movements daily), and diarrhea.

Interestingly, the study highlights that the healthiest bowel movement frequency was observed in the high-normal group, i.e., individuals who reported bowel movements one to two times per day. These individuals exhibited a higher count of fiber-fermenting gut bacteria that is often linked to optimal health.

Johannes Johnson-Martinez, a PhD candidate at ISB and the primary author of the study, commented:

“Prior research has shown how bowel movement frequency can have a big impact on gut ecosystem function.”

He continued, “Specifically, if stool sticks around too long in the gut, microbes use up all of the available dietary fiber, which they ferment into beneficial short-chain fatty acids. After that, the ecosystem switches to fermentation of proteins, which produces several toxins that can make their way into the bloodstream.”

Contrastingly, constipation and diarrhea present on the extremes of the bowel movement frequency spectrum were associated with potential health threats. The study pointed out decreased kidney function in individuals who experienced less frequent bowel movements and fell under the ‘constipated’ category.

The research revealed that p-cresol-sulfate and indoxyl-sulfate, toxins produced by microbes due to protein fermentation and known to harm kidneys, were found to be predominant in the blood of constipated individuals.

“‘Here, in a generally healthy population, we show that constipation, in particular, is associated with blood levels of microbially derived toxins known to cause organ damage, prior to any disease diagnosis,” said Sean Gibbons, PhD, ISB associate professor and the paper’s corresponding author.

Conversely, the study discovered a correlation between diarrhea and “higher levels of inflammation and blood markers of reduced liver function,” as Gibbons reported to Today.

According to Gibbons, “Overall, this study shows how bowel movement frequency can influence all body systems, and how aberrant bowel movement frequency may be an important risk factor in the development of chronic diseases.” He went on to stress that these findings could help in formulating strategies to manage bowel movement frequency, optimizing health and wellness even amongst healthy populations.

For those looking to improve their bowel movement habits, gastroenterologist Will Bulsiewicz, MD MSCI, who wasn’t part of the study, suggests increasing fiber intake. He informs us that “95 percent of Americans are deficient in fiber,” emphasizing that “Fiber helps to normalize our bowel movements and get us into that sweet spot where the gut microbiome is optimally healthy and our bowels are moving at just the right pace, without diarrhea or constipation.”

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Your Guide to 15 Top Foods for Managing High Blood Pressure According to Doctors

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Embarking on a heart-healthy journey involves more than just exercise; it involves making significant dietary choices. Incremental changes to your eating habits can greatly impact your heart health, especially if you suffer from high blood pressure. Certain foods are known to support cardiovascular health and offer blood pressure regulation properties. Here, we collate advice from top doctors to list 15 nutritious foods that can help you maintain a healthy blood pressure.

1. Low-Sodium Foods

Reducing sodium intake can contribute to lowering your blood pressure. Stephen Vogel, MD, advises that cooking food at home allows control over salt content, and choosing low-sodium options when dining out can also help.

“Water retention puts stress on your arteries, just like cranking up your garden hose,” says Vogel.

2. Berries

Berries like blackberries, raspberries, strawberries, and blueberries are rich in antioxidants that help stabilize blood pressure. Blueberries are particularly beneficial due to their high anthocyanin content, says cardiologist Nieca Goldberg, MD.

3. Fish

Fish, especially those high in omega-3 fatty acids like salmon and trout, can assist in lowering blood pressure. Vogel suggests incorporating at least two servings of fish per week into your diet to benefit from its lean protein and healthy fats.

4. Olive Oil

Substituting less healthy fats with extra virgin olive oil can help reduce blood pressure. This monounsaturated fat is rich in polyphenols, which are linked to better metabolic health according to Vogel.

5. Vegetables

Vegetables not only have a low sodium content but are also high in fiber. Vogel notes that consuming 25 to 30 grams of fiber per day can improve blood pressure.

6. Beets

Beets offer benefits beyond their high fiber content. They are rich in natural chemicals that can improve blood pressure upon conversion to nitric oxide in the body, explains Vogel.

7. Almonds

Almonds, rich in healthy fats and magnesium, are beneficial for blood pressure regulation, blood sugar control, and cholesterol management, Vogel points out.

8. Broccoli

Regular consumption of broccoli, due to its high calcium and magnesium content, is associated with lower blood pressure, Goldberg suggests.

9. Bananas

Bananas, an excellent source of potassium, can help regulate blood pressure, says Daniel Landau, MD.

10. Avocados

Avocados are another high-potassium food, beneficial in lowering the risk of hypertension and improving blood pressure levels, according to Goldberg.

11. Beans and Legumes

Beans and legumes, high in fiber, potassium, calcium, and magnesium, can help lower blood pressure, as noted by Goldberg.

12. Oatmeal

Oats, rich in beta-glucan, can support heart health and blood pressure control, Landau advises.

13. Cinnamon

Cinnamon, used regularly, can help maintain healthy blood pressure. Landau recommends adding it to oatmeal for a potent blend.

14. Yogurt

Yogurt, high in calcium and potassium, can aid in lowering blood pressure, states Goldberg.

15. Fruits – Kiwi and Citrus

Kiwis and citrus fruits like oranges are good choices to lower blood pressure due to their high potassium and flavonoid content, Goldberg concludes.

Adopting a heart-healthy diet is more than just about single food choices; it’s about creating sustainable habits that positively impact overall health. So, go ahead, revamp your meal plan, incorporate these heart-supporting foods, and take a step towards a healthier, happier heart.

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Discover the Speech Clues That May Signal Cognitive Health Changes

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As our age advances, so do the health risks we face. Among these, cognitive decline, often a harrowing symptom that may signal dementia and Alzheimer’s disease, is particularly frightening. Though risk factors and early indications of cognitive decline have been deeply researched, new findings continue to emerge. A recent study from November 2023, published in Aging, Neuropsychology, and Cognition, has discovered a speech pattern that could potentially serve as an early warning sign of cognitive decline.

The study was conducted by researchers from Baycrest’s health science center and the University of Toronto. They examined whether patterns in speech could predict the onset of cognitive decline. Previous research suggested word-finding difficulty (WFD) as a potential indicator, but this is also a common sign of aging. The pace of speech, whether fast or slow, however, might offer a clearer warning signal.

Jed Meltzer, PhD, Baycrest’s Canada Research Chair in Interventional Cognitive Neuroscience and lead author of the study, said in a press release, “Our results indicate that changes in general talking speed may reflect changes in the brain.” He added, “This suggests that talking speed should be tested as part of standard cognitive assessments to help clinicians detect cognitive decline faster and help older adults support their brain health as they age.”

This groundbreaking study evaluated both talking speed and WFD in adults across a broad age range of 18 to 90 years. All 125 participants underwent three different assessments, including a picture-naming game which tested their ability to identify and name the images while ignoring distracting words played through headphones.

The second assessment tasked participants with describing two complex pictures within sixty seconds each. Their speech pace and pauses were analyzed using AI technology. The final assessment comprised of standard tests to evaluate various mental abilities, including executive function.

Post the completion of these assessments, researchers found that WFD and certain other abilities tend to decrease with age – an expected outcome. However, what intrigued them was that the reduced ability to recognize and remember an object’s name in a picture was not connected to a decline in other mental skills. Furthermore, there was no link between pauses while finding words and brain health.

The press release explains: “Instead, how fast participants were able to name pictures predicted how fast they spoke in general, and both were linked to executive function. In other words, it wasn’t pausing to find words that showed the strongest link to brain health, but the speed of speech surrounding pauses.”

Therefore, the researchers concluded that a noticeable slowdown in normal speech could be a more significant marker of cognitive decline than struggling to find the right words. However, this connection needs further exploration, and researchers suggest repeating these tests with the same participants over several years to confirm if speech speed indeed forecasts cognitive decline.

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