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Finasteride: Unexpected Heart Health Benefits Unveiled in Study

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Finasteride, a drug widely recognized under the brand names Propecia and Proscar, has been a go-to treatment for male pattern baldness and enlarged prostate for countless men. However, recent research has unveiled some unexpected benefits of this medication.

A study conducted by the University of Illinois Urbana-Champaign has linked this “miracle drug” to cholesterol-lowering effects and a decrease in heart disease risk. The research, published in the Journal of Lipid Research, revealed that men who used the drug had, on average, 30 points lower cholesterol levels than those who did not.

This data was originally gathered as part of the National Health and Nutrition Examination Survey conducted between 2009 and 2016. Further research involving mice showed that the use of the drug for 12 weeks, in conjunction with a high-fat, high-cholesterol “Western” diet, resulted in reduced cholesterol, slower plaque buildup in the arteries, and decreased liver inflammation, among other benefits.

“The most surprising finding was the human data,” said Jaume Amengual, lead study author and assistant professor in the Department of Food Science and Human Nutrition and the Division of Nutritional Sciences at the University of Illinois. “When we observed the association with finasteride and plasma lipids, we decided to do our mouse study.”

Finasteride works as a hair loss treatment by blocking a protein found in hair follicles. When treating an enlarged prostate, the drug inhibits the prostate gland that activates testosterone. Given that atherosclerosis, a condition characterized by cholesterol plaque buildup in the arteries, is most prevalent among men and has been linked to the male hormone testosterone, the researchers were prompted to investigate whether the medication could also reduce heart disease risk.

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, who was not involved in the study, explained the implications of finasteride. “It stops testosterone from turning into dihydrotestosterone and thereby stops hair loss and also shrinks the prostate by 25%,” he said. However, he cautioned that side effects can include depression, anxiety, and impotence.

Dr. Brett Osborn, a Florida neurologist and longevity expert, also not involved in the study, provided his insights on the drug. “Finasteride in normal dosages — 1 to 5 mg daily, depending upon the indication — has intolerable side effects in many,” he said. “It can also strip a man of his energy, virility, libido, and motivation.”

The study did have some limitations, the researchers noted. Out of nearly 4,800 total participants, only 155 were finasteride users, all of whom were men over 50. The survey also did not determine the duration or amount of the doses. “We also did not examine the effects of finasteride in women or female mice,” Amengual said. “However, this drug is not prescribed for women, as it could be dangerous during pregnancy.”

Despite these limitations, the researchers are optimistic about the potential of finasteride in combating cardiovascular diseases. “There is still so much to discover on how finasteride works in our body,” Amengual noted. “But based on our findings, this drug could be another tool in the fight against cardiovascular diseases.”

In response to the drug being found to lower cholesterol and decrease heart disease risk, Siegel also called for more research. “Much larger studies are needed in humans to confirm these findings before you would ever consider using this drug for cardioprevention,” he said. “It may end up being useful for this purpose in the elderly, who are at higher risk of heart attacks and strokes, as an add-on statin therapy.”

Osborn also pointed out that the study was performed retrospectively, meaning there was no control group, and random effects unknown to the researchers could have influenced the results. “That said, the authors’ observations are interesting and demand further investigation,” Osborn stated. “After all, lipid-lowering agents are one of the mainstays of cardiovascular risk reduction — and most Americans die vascular deaths.”

Osborn cautioned that this study does not mean every male should start taking finasteride. Instead, he recommends regular exercise, increasing daily fiber intake to 25 grams, and taking high doses of omega-3 fatty acids to reduce cardiovascular risk. “For now, skip the finasteride as a lipid-lowering agent,” he advised. “As it stands now, the juice isn’t worth the squeeze.”

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Fresh Concerns: Top 12 Produce Items High in Pesticides

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While we often consider fruits and vegetables as the healthier alternatives to processed snacks, the reality may be more complex. The Environmental Working Group (EWG), a health advocacy organization, releases an annual guide to inform consumers about the levels of pesticides present in produce. On March 20, the EWG unveiled its 2024 “Dirty Dozen” list, highlighting the 12 fruits and vegetables most contaminated with pesticides.

The latest report from the EWG is based on data from tests conducted by the U.S. Department of Agriculture (USDA) and the Food and Drug Administration (FDA). These tests involved 47,510 samples from 46 different types of fruits and vegetables.

“The USDA peels or scrubs and washes produce samples before they’re tested, whereas the FDA removes only dirt first,” the EWG clarified in its report.

Despite these cleaning methods, the tests detected 254 different pesticides in the produce samples.

“Pesticides are chemicals designed to kill living organisms that are considered pests, including insects, weeds and mold. Even after washing fruits and vegetables, pesticide residues remain on produce,” the EWG elaborates on its website. “Research shows that certain pesticides used on American produce are linked to cancer, hormone disruption, and cognitive and behavioral problems.”

The four pesticides most commonly found in the produce on the Dirty Dozen list were fludioxonil, pyraclostrobin, boscalid, and pyrimethanil, which are also fungicides, the EWG noted.

“Emerging evidence suggests many widely used fungicides may disrupt human hormone systems,” stated EWG senior toxicologist Alexis Temkin, PhD. “But more studies are needed to better understand the risks they—and all pesticides—pose to humans, particularly children.”

To protect yourself, the EWG advises purchasing organic versions of any produce on the Dirty Dozen list. The following fruits and vegetables have been identified as the most pesticide-contaminated, according to the organization’s recent report.

The EWG warns that green beans may contain traces of two insecticides, acephate and methamidophos, which have been associated with harm to the developing nervous system. These chemicals were found in approximately 8 percent of the non-organic green bean samples tested by the USDA in 2021 and 2022.

Blueberries have secured the 11th spot on the EWG’s Dirty Dozen list for two consecutive years.

“The most troubling pesticides found on blueberries were phosmet and malathion, chemicals known as organophosphate insecticides,” the EWG reported. “They kill many types of insects and are toxic to the human nervous system, especially children’s developing brains.”

Over 90 percent of cherry samples tested positive for residue of two or more pesticides, the EWG’s report revealed. The chemicals of concern found on this fruit were pyraclostrobin, linked with liver toxicity and metabolic disorders, and boscalid, associated with cancer and thyroid dysfunction.

Bell and hot peppers were found to have the second highest amount of individual pesticides, with 101 different chemicals detected on these items, according to the EWG.

Apples typically contain more than four different pesticides, some at high concentrations, the EWG warned.

Like cherries, over 90 percent of nectarine samples tested positive for residues of two or more pesticides.

The EWG reported an increase in the number of chemicals found on pears over the years. In its latest report, the organization found that over 60 percent of non-organic pears tested by the USDA contained traces of five or more pesticides, a significant increase from previous tests.

Almost all peaches are contaminated with pesticides, the EWG warned.

“A single peach sample could have traces of up to 19 different pesticides,” the organization stated.

The EWG’s new report also indicated that over 90 percent of grapes tested positive for two or more pesticides.

Kale, collard, and mustard greens were found to have the most pesticides, with 103 individual chemicals detected across these items, according to the EWG.

Spinach, another leafy green, tested positive for an average of seven different pesticides, including permethrin, which has been banned for use on food crops in Europe since 2000.

“At high doses, permethrin overwhelms the nervous system and causes tremors and seizures,” the EWG cautioned.

Strawberries topped the EWG’s Dirty Dozen list, as they are the “fresh produce item most likely to be contaminated with pesticide residues, even after they are picked, rinsed in the field and washed before eating,” the organization reported.

“The average American eats about eight pounds of fresh strawberries a year—and with them, dozens of pesticides, including chemicals that have been linked to cancer and reproductive damage, or that are banned in Europe,” the EWG warned.

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40-Year-Old Mom Reveals Unexpected Signs of a Life-Threatening Heart Attack

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Heart health is a topic that gains more attention as we age. However, it’s not often a primary concern for middle-aged individuals, particularly women. A 40-year-old mother who recently suffered a “widowmaker” heart attack is now advocating for awareness of the unexpected symptoms she experienced prior to her cardiac event. This article aims to highlight these warning signs to promote safety and early detection.

“Widowmaker” heart attacks are severe medical emergencies, named for their high fatality rate. They occur when the left anterior descending (LAD) artery, which supplies half of the heart’s blood, becomes completely blocked due to cholesterol buildup, as explained by the Cleveland Clinic. This blockage deprives the heart muscles of blood, leading to their death.

“The ‘widowmaker’ is a lay term for a particular type of heart attack,” said Gary Niess, MD, an interventional cardiologist with Novant Health Heart & Vascular Institute. “Any artery closure can cause a heart attack where the heart muscle dies, but the widowmaker has a higher rate of mortality.”

Heart attacks are distressingly common, with over 800,000 people in the U.S. experiencing them each year. This equates to approximately one heart attack every 40 seconds. Heart attacks remain the leading cause of death for both men and women in the U.S.

The Cleveland Clinic states that the risk of heart attacks increases for men and people assigned male at birth (AMAB) starting at age 45, and for women and people assigned female at birth (AFAB) at age 50. However, heart attacks can occur at any age, as demonstrated by a 40-year-old woman named Jessica Charron.

In 2022, Charron began to feel unusual symptoms, including a tingling sensation that traveled down her neck to her back and arms, accompanied by chills. Initially, she attributed these symptoms to spending too much time outside on a hot day. However, as the symptoms intensified and came in waves, she realized something more serious might be happening.

“I just knew something was wrong,” she told Today. “I felt like this is just not a normal chill—not even a flu-like chill. It was different. It was more intense.”

Despite initial tests at the hospital not revealing any issues, Charron insisted something was wrong. Eventually, doctors discovered she was experiencing a “widowmaker” heart attack, with an 85 percent blockage in her LAD.

“I was absolutely shocked,” Charron told Today. “There was nothing leading up to that which would have indicated that I would be a candidate for a heart attack.”

Charron underwent surgery to place a stent in her artery and later had a triple bypass to address two other blockages. She now emphasizes the importance of awareness of heart disease risks, especially for women and AFAB individuals.

“I was young. I was healthy,” she told Today. “The biggest lesson learned for me is that heart disease doesn’t really discriminate.”

Laura Mauri, MD, chief scientific, medical, and regulatory officer at Medtronic, listed chest pain or pressure, shortness of breath, excessive sweating, and pain in the neck, arm, or back as common warning signs of a heart attack. However, symptoms can vary between individuals and genders. Quick action is crucial in surviving a heart attack.

“When you’re in an ambulance, getting early treatment actually saves lives,” Mauri told Today. “The good news is that in many cases, if a heart attack is detected early, the treatment can be pretty quick and not lead to a long hospitalization and lead to a full recovery. It’s not uncommon that people recovering from a heart attack go back to living even healthier lifestyles than they did before the heart attack.”

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Hidden Dangers: 5 Common Supplements That Can Harm Your Liver

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Supplements are often seen as a beneficial addition to a healthy lifestyle, providing those necessary vitamins and minerals that might be missing from our diets. However, it’s important to remember that not all supplements are created equal. Some can even pose a risk to our vital organs, including the liver.

The liver plays a crucial role in detoxifying the body, as Alyssa Smolen, MS, RDN, a New Jersey-based registered dietician, explains. “Your liver naturally detoxifies the body. That’s its primary job,” she says. “However, too much of certain substances can harm the body’s ability to do this—including specific supplements that can interfere with this process.”

Given this, medical professionals emphasize the importance of monitoring what we consume and reducing or eliminating anything that could be harmful. Here are five supplements that could potentially damage your liver, as per doctors’ advice.

Green tea, while a popular beverage, can also be found in extract form as a supplement. However, Leann Poston, MD, a licensed physician and health expert for Invigor Medical, warns that it can cause liver injury in some individuals. “Unfortunately, it is currently unknown why it causes liver damage in some people and not others,” she reveals.

Sarah Alsing, MS, RD, owner of Delightfully Fueled, further cautions that green tea extract is often an ingredient in diet pills. “If you are looking into supplements advertised for weight loss, then make sure you read the label to see if it’s an ingredient,” she advises.

Black cohosh, a traditional herbal remedy often used to treat menopause symptoms, has also been linked to liver injury. “There have been case reports that link the herbal supplement black cohosh to liver injury,” says Nesochi Okeke-Igbokwe, MD, medical expert and CEO of Dr. Nesochi internal medicine practice. “However, more studies are needed to further investigate the use of this supplement with potential hepatotoxicity.”

Niacin, or vitamin B3, is essential for the body to convert food into energy, produce stress-related hormones, and improve circulation, according to Alsing. “It also aids with cholesterol control,” she adds. However, she warns that “high doses of niacin can damage the liver and affect coagulation, which is the body’s way of preventing excessive bleeding.”

Ground kava root, traditionally used in the Polynesian islands as a relaxation aid, can also be harmful to the liver when consumed in high amounts. “Just like alcohol, it can be harmful to the liver when consumed in high amounts,” warns Danielle Arnold, MS, LDN, clinical support specialist at Designs for Health. “In fact, some tradition states that kava was originally chewed and spit out because enzymes in the spit deactivate some of the liver-toxic compounds it contains.”

Finally, Vitamin A, while essential for vision and immunity, can cause liver damage when taken in excessive amounts. “Vitamin A doses that fall within the recommended daily allowance (RDA) are not associated with liver injury,” says Poston. “However, doses more than 100 times the RDA can cause acute liver injury. Excessive vitamin A can damage specialized liver cells, causing liver scarring and injury.”

While this information is based on expert advice and research, it’s always best to consult with your healthcare provider directly regarding any concerns about your medication or health.

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