Nutrition
Researchers Reveal How a Popular Supplement May Affect Your Medications
Cinnamon is a beloved spice, often enjoyed in lattes, baked goods, and teas. Its active compound, cinnamaldehyde, is known for its anti-inflammatory properties and potential to stabilize blood sugar levels. This has led many to turn to cinnamon supplements. However, recent research highlights a need for caution, as these supplements may interact with certain medications.
A study published in the journal Food Chemistry: Molecular Sciences explored the interactions between cinnamaldehyde and specific medications using cellular models. Researchers from the University of Mississippi’s National Center for Natural Products Research discovered that cinnamaldehyde “activates receptors that control the metabolic clearance of medication from the body, meaning consuming large amounts of cinnamon could reduce the effects of drugs,” according to their press release.
The study identified four medications that could be affected by cinnamon supplements. Study author Shabana Khan emphasized the risks, stating, “Health concerns could arise if excessive amounts of supplements are consumed without the knowledge of health care provider or prescriber of the medications.” She further explained that “overconsumption of supplements could lead to a rapid clearance of the prescription medicine from the body, and that could result in making the medicine less effective.”
While dietary cinnamon is generally safe, the concentrated doses found in supplements pose a greater risk of interaction. The type of cinnamon also plays a crucial role in potential interactions. Cinnamon oil, often used in topical products and as a flavoring agent, “presents almost no risk of herb-drug interactions.”
Conversely, Cassia cinnamon, a common and less expensive variety from southern China, contains high levels of coumarin, a compound known for its blood-thinning properties. Amar Chittiboyina, associate director of the natural products center, warned, “Coumarin’s anticoagulant properties can be hazardous for individuals on blood thinners.”
For those concerned about coumarin, Ceylon cinnamon from Sri Lanka is a safer choice. “True cinnamon from Sri Lanka carries a lower risk due to its reduced coumarin content,” Chittiboyina noted.
The researchers suggest that further clinical trials are necessary to fully understand how cinnamaldehyde affects drug metabolism. Until then, they recommend consulting with a healthcare provider before starting cinnamon supplements, especially for individuals with chronic conditions.
“People who suffer from chronic diseases—like hypertension, diabetes, cancer, arthritis, asthma, obesity, HIV, AIDS, or depression—should be cautious when using cinnamon or any other supplements,” Khan advised. “Our best advice is to talk to a health care provider before using any supplements along with the prescription medicine.”
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